We use necessary cookies that allow our site to work. We also set optional cookies that help us improve our website.

For more information about the types of cookies we use, and to manage your preferences, visit our Cookies policy here.

Cookie settings

Understanding Your Risk

Living with a Genetic Fault

You’ve been through genetic testing and found out you have a genetic fault. This means your chance of getting some cancers is higher than someone without the mutation. But don’t worry—this doesn’t mean you will definitely get cancer. Here’s what you need to know.

Understanding Your Risks

A positive test means you have a higher chance of developing certain cancers, including ovarian cancer.

Your genetics team will explain your specific risks and give you a letter with information about your mutation and the associated risks.

Here’s an idea of what having a genetic fault could mean for you.

BRCA1 and BRCA2

If you have a mutation in your BRCA1 or BRCA2 gene, your risk of cancer increases. This doesn’t mean you will definitely get cancer, but your chances are higher. Here’s a look at your risk by age 70:

  • BRCA1: No significant increased risk of ovarian cancer until age 45. Risk increases at ages 45-49 and again at ages 55-59.
  • BRCA2: Risk increases later, but you should still consider the ages your relatives developed ovarian or breast cancer.
Screenshot 2024-06-24 at 14.59.41

(There is research suggesting an increased risk of pancreatic cancer for people who have these mutations, but research is ongoing into how much they increase risk.)

Note: men can get breast cancer too.

It’s important to understand that the figures above are risks for your whole life. Another way of looking at your risk is to look at what age the risk increases:

Risks of breast and ovarian cancer for BRCA1 and BRCA2 by age

Here’s a look at your risk by age 70:

  • BRCA1: No significant increased risk of ovarian cancer until age 45. Risk increases at ages 45-49 and again at ages 55-59.
  • BRCA2: Risk increases later, but you should still consider the ages your relatives developed ovarian or breast cancer.
pasted image 0

Graphs adapted from Antoniou et al. AJHG 2003

pasted image 1

Graphs adapted from Antoniou et al. AJHG 2003

Lynch Syndrome

A mutation in one of the genes linked to Lynch Syndrome will mean you are at an increased lifetime risk of cancer. Remember, this is an increased chance of cancer, not a guarantee you will get cancer in your lifetime.

The table below shows estimated risk by age 70.

Screenshot 2024-06-24 at 15.02.37

Lynch Syndrome

Key Takeaways

  • Higher Risk, Not a Guarantee: Having a genetic fault means a higher chance of cancer, but it doesn’t mean you will definitely get it.
  • Talk to Your Genetics Team: They will explain your specific risks and give you a letter with important information.
  • Consider Family History: The age your relatives got cancer can affect your risk, so discuss this with your genetic counsellor.

Living with a genetic fault can be challenging, but knowing your options and talking to your family can make a big difference. You are not alone—there are many people and resources to help you along the way.

If you have any questions please contact Jo@ovarian.org.uk

Related content