Why do some ovarian cancer tumours become resistant to chemotherapy?

Dr Bob Brown
Professor Bob Brown, Ovarian Cancer Action Research Centre

Understanding why tumours develop resistance to chemotherapy is essential as ovarian cancer recurs in 70-90% of cases. Professor Bob Brown studies how ovarian cancer tumours develop this resistance to treatment so we can find a way to prevent this from happening. His lab has already discovered the epigenetic changes that occur during chemotherapy can have many effects on the tumour, some of which could make a tumour more sensitive to new molecularly-targeted drugs or immune therapies.

What’s next?

By examining epigenetics in recurring tumours, Professor Brown aims to identify biomarkers that could help women with ovarian cancer receive more personalised treatments, including new drugs via clinical trials.