Why are some ovarian cancer tumours particularly aggressive?

Professor Iain McNeish
Professor Iain McNeish, Director, Ovarian Cancer Action Research Centre    

All cancer cells contain specific mutations in their DNA, which cause the cells to grow uncontrollably. Around 20 - 25% of ovarian cancers contain mutations in a gene called PTEN; these tumours grow more rapidly and are less likely to be detected by the immune system. Professor Iain McNeish investigates why tumours with PTEN mutations avoid detection by the immune system. 

What’s next?

Professor McNeish aims to take his research to a clinical trial in women with PTEN-mutated ovarian cancer using drugs that are already available. If successful, these trials could lead to better survival for women with these cancers.